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Use of epidemiologic findings
in regulatory actions, corporate decision making, legal decisions, media
venues, and citizen action, among other policy arenas.
by CRC Press, Inc.
Guidelines on risk assessment have suggested that epidemiologic
studies can detect only comparatively large increases in the relative risk
of cancer (U.S. EPA
a, ).. While this is true for the more traditional epidemiologic
studies that use cancer morbidity and mortality statistics, molecular
approaches should greatly increase the sensitivity of epidemiologic studies
to detect increased risks of cancer. This will be a major direction in risk
assessment over the next to years.
A second major account forex ira managed Biologic mechanism. No point estimate of the carcinogenic potency of a substance will apply to all individuals in the population. The NRC recommended that federal agencies undertake research to explore and elucidate the relationships between variability in each measurable factor (e.g., DNA adduct formation) and variability in susceptibility to carcinogenesis. managed account They also recommended that guidance be provided on how to construct appropriate samples of the population for epide- miologic studies and risk extrapolation, given the influence of susceptibility varia- tion. A third major focus for epidemiology and risk assessment in the coming years will be increased international collaboration on epidemiologic. Research. As occupa- tional and environmental controls have diminished exposure to carcinogens in devel- oped countries, much attention has turned to epidemiologic study in the developing countries, including those in Eastern Europe. Collaboration on a variety of epide- miologic issues such as molecular methods and the collection and presentation of account forex ira managed Data on exposure response will maximize the datas utility for risk assessment. REFERENCES Blair, A., Burg, J., Foran, J., Gibb, H., Greenland, S., Morris, R., Raabe, G., Savitz, D., Teta, J., Wartenberg, D., Wong, O., Zimmerman, R., Guidelines for application of meta- analysis in environmental epidemiology, Regulat Toxicol Pharmacol, ,.
, International Agency for Research on Cancer, Lyon, France, , Preamble. International Life Science Institute, Low-dose extrapolation of cancer risks: current perspec- tives and future directions, ILSI Risk Science Institute, Washington, DC, . by CRC Press, Inc. Johns Hopkins School of Public Health, Public Health Newsletter, Johns Hopkins School of. |